Jean Thomas, aka The Nurse, is the manager of the Hotel Artemis, an ultra-exclusive, members-only hospital hidden in a hotel redolent of faded 20s glamour. One night, as a violent riot rages on the streets of Los Angeles, legendary crime boss Orian Franklin, aka Niagara, arrives needing immediate treatment after a failed attempt on his life. Niagaras sudden arrival creates a violent clash among the criminals in the hospital, with one patient having a particularly deadly motive for checking into the hotel.